• Start date:
  • 14 November 2019
  • Duration:
  • 1 day
  • Working as:
  • Medical specialist

How do laboratory specialists and medical laboratories contribute to better patient outcome and more effective treatment? During this symposium we define health and disease at a molecular level on the basis of Clinical Proteomics. The potential of precision diagnostics is also examined. Do you want to know more? Please register timely via the registration link on this page.

Clinical evidence
To contribute to patient care in an efficient and effective way, it is important to rationalize the clinical needs. We will address the clinical needs question during the symposium. In addition to this, we will discuss the positioning of medical tests in clinical care pathways and to the generation of clinical evidence. Another important objective of the symposium is to bring clinical chemistry laboratory specialists together with other stakeholders of the biomarker - medical test pipeline.


The symposium is a collaboration between Boerhaave Continuing Medical Education and the Department of Clinical Chemistry and Laboratory Medicine of the Leiden University Medical Center (LUMC). The lectures will be given by renowned speakers in the field of Test Evaluation, Test Standardization and Clinical Proteomics.

08:30 Registration
09.30 Welcome
Prof.dr. Christa Cobbaert
  Basics of the EFLM Test Evaluation framework and the unmet clinical needs checklist
Chair: Prof. dr. Christa Cobbaert
09.40 Basics of the EFLM Test Evaluation framework and the unmet clinical needs checklist
Prof. dr. Patrick Bossuyt
  Applying the basics for test (panel) selection and clinical pathway redesign
Chair: Prof. dr. Christa Cobbaert
10.15 The nephrologist viewpoints regarding desirable urine diagnostic support & clinical pathways for reducing kidney injury in secondary and tertiary care hospitals
Prof. dr. Hans de Fijter and Dr. Darius Soonewala
11.00 The researcher's rationale for selecting a multiplexed biomarker panel for kidney injury based on clinical chemistry needs
Tirsa van Duijl
11.25 Predefining clinical performance specifications of potentially useful tests for colorectal cancer screening, as addition to the current iFOBT
Dr. Wilbert van den Hout
11.50 Interactive: Questions and answers
Host: Prof. dr. Christa Cobbaert
12.00 Lunch
  Exploring the potential of (glyco-)proteoforms as future medical tests by means of enabling technology
Chair: Prof. dr. Christa Cobbaert and Dr. Renee Ruhaak
13.00 Potential of multiplexed MS-based serum apolipoprotein profiling for improved and stratified management of CVD patients
Prof. dr. Christa Cobbaert
13.30 Understanding the antithrombin measurand using an MS-based antithrombin proteoform method
Dr. Renee Ruhaak
14.00 An additional layer of clinical information beyond the imperfect total PSA: challenges and opportunities for GLY-PSA?
Dr. Yuri van der Burgt
14.30 Coffee break
  Adopting the metrological traceability and commutability concepts into quantitative proteomics applications right from the start: the serum apolipoprotein profile example
Chair: Prof. Andy Hoofnagle
14.50 Confounded Lp(a) test results masked clinical utility of Lp(a) test for decades
Prof. Dr. Gerhard Kostner
15.20 The relevance of developing an IFCC MS-based multiplex apoprotein profile method addressing unmet CVD needs
Prof. Uta Ceglarek
15.45 Development of SI-traceable primary reference materials for quantitative proteomics of apolipoproteins
Dr. Vincent Delatour
16.10 Development of SI-traceable and commutable secondary reference materials for quantitative proteomics of apolipoproteins
Dr. Liebet Deprez
16.30 Interactive: Questions and answers
Chair: Prof. Andy Hoofnagle and host: Prof. dr. Christa Cobbaert
16.45 Reception





P.M. Bossuyt
Y.E.M. van der Burgt
Prof. Ceglarek
Prof. Dr. C.M. Cobbaert
Dr. V. Delatour
Dr. L. Deprez
Mr. T.T. van Duijl
J.W. de Fijter
Interne Geneeskunde Leids Universitair Medisch Centrum (LUMC)
Prof. A. Hoofnagle
dr. W.B. van den Hout
Prof. dr. G. Kostner
Dr. L.R. Ruhaak
D. Soonawala
Rijnsburgerweg 10, 2333 AA Leiden

Building: LUMC Poortgebouw Zuid

Extra information: 1st floor

Location: Leiden

Regular fee € 150,-
Trainee fee € 100,- (€50,- discount)