• Start date:
  • 10 February 2020
  • Duration:
  • 5 days
  • Working as:
  • PhD

The LUMC course ‘Basic Methods and Reasoning in Biostatistics’ covers the fundamental toolbox of biostatistical methods plus a solid methodological basis to properly interpret statistical results. The course is a mandatory part of the LUMC Graduate School Program and a prerequisite for any of the advanced biostatistical courses offered by the LUMC.
The course is given during a single week, followed by a final examination on the next Tuesday.

In this course we will cover the basics of biostatistics and participants will learn how to analyze practical problems in medical research using statistical software. Subjects covered are among others: descriptive statistics, principles of statistical estimation and testing, cross tabulation and chi-square test, Student t-test and the correspondence with non-parametric counterparts, simple regression and correlation, introduction to analysis of variance, study design, interpretation of observational data, bias, multiple testing, good statistical practice, sample size calculation, pros and cons of p-values.

week: 10-14 February 2020
exam Tuesday 18 February 2020

Registration on Monday: 09.00 - 09.30

Every day from 08.45 - 17:00

  • At the beginning of each day except Monday, the material of the previous day is discussed during a general question session from 08.45 - 09.30 followed by 2 lectures.
  • The material of Friday will be discussed on Monday 17 February 2019 from 9-10 in lecture hall J1-83 of the main building
  • Every afternoon participants work individually in the electronic learning environment on their own PCs/laptops on their own workplace. For participants who do not have their workplace at the LUMC we booked a separate room where you can work.
  • Please note that you have to sign the attendance list every day

Make sure you have either SPSS or R (according to your preference) installed on your computer to work through the exercises. Non-LUMC participants with a non-windows PC (like a Mac) should make sure they obtain and install a (evaluation version of) SPSS or R before the course. You can find an SPSS trial version at https://www.ibm.com/analytics/spss-trials. . R is a free software environment and can be downloaded from the R project website. All LUMC participants should make sure they have access to SPSS or R and should work on their own PCs at any location convenient for them. Contact the ICT department if you need help with the installation.


Secondary school mathematics. No prior knowledge of biostatistics required.

Teaching environment

Lectures and e-learning including practical sessions with SPSS or R.

Recommended book

(for reference purposes only; not used during course)
Aviva Petrie & Caroline Sabin,
Medical Statistics at a Glance.
ISBN 0-632-05075-6


The exam will take place on Tuesday 18 February 2020 in the main building, J1-82 and J1-84

Please note: after February 3th it is not possible anymore to switch from exam time slot. 

Coordinators and teachers: Dr. N. van Geloven and Dr. M.D.M. Rodrigues Girondo, dep. of Biomedical Data Sciences

For more information

Please see this introductory video about the course: video 
and www.boerhaaveboard.nl (only during the course)

Program (draft) 

Monday 10 February 2020

09:00 Registration: Lecture hall 5 
09:30 Introduction 
10:30 Break 
10:45 Design 
11:45 E-learning Descriptive Statistics
17:00 Finish E-learning 

Tuesday 11 February 2020

09:00 Question session 
09:30 Distributions and bootstrap 
10:30 Break 
10:45 DAGs and Bias I 
11:45 E-learning Principles of statistical testing 
17:00 Finish E-learning 

Wednesday 12 February 2020

09:00 Question session 
09:30 Good Statistical Practice
10:30 Break 
10:45 Multiple testing 
11:45 E-learning Comparing numerical variables 
17:00 Finish E-learning 

Thursday 13 February 2020

09:00 Question session 
09:30 Bias II and III
10:30 Break 
10:45 Sample size calculation 
11:45 E-learning Comparing categorical variables 
17:00 Finish E-learning 

Friday 14 February 2020 

09:00 Question session 
09:30 Hypothesis testing recap 
10:30 Break 
10:45 Hypothesis testing revisited
11:45 E-learning Linear regression and correlation 
17:00 Finish E-learning 

Monday 17 February 2020 

09:00 - 09:30 Question session 

Tuesday 18 February 2020

09:00 - 18:00 Exam 
Albinusdreef 2, 2333 ZA Leiden

Participation fee for employees LUMC/PhD Students    €  150

Participation fee outside LUMC                                      €  950

Bachelor/master students of the Leiden University are free of charge**  
**Participation is free of charge for bachelor and master students of the Leiden University but only when you fill in your student email address and your student number.

Please be informed that we can ask you to show your student pass at the registration desk.

Please note that a fee will be charged to LUMC students who do not attend courses or who are too late with cancelling their participation of the course.

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